Effect of UV absorbers on UV-induced mutagenesis in E. coli B/r.
نویسندگان
چکیده
منابع مشابه
UV - Induced Mutagenesis in Lactic Acid Bacteria
Induced mutagenesis is widely used for selection of microorganisms producing biologically active substances and further improving of their activities. However, it is rarely used toward lactic acid bacteria (LAB) due to their genetic specificity. Determination of LABs sensitivity to UV light and evaluate the effectiveness of UV-induced mutagenesis by positive selection of antibiotic resistant mu...
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متن کاملLack of strand bias in UV-induced mutagenesis in Escherichia coli.
We have investigated whether UV-induced mutations are created with equal efficiency on the leading and lagging strands of DNA replication. We employed an assay system that permits measurement of mutagenesis in the lacZ gene in pairs of near-identical strains. Within each pair, the strains differ only in the orientation of the lacZ gene with respect to the origin of DNA replication. Depending on...
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Ultraviolet (UV) light induces specific mutations in the cellular and skin genome such as UV-signature and triplet mutations, the mechanism of which has been thought to involve translesion DNA synthesis (TLS) over UV-induced DNA base damage. Two models have been proposed: "error-free" bypass of deaminated cytosine-containing cyclobutane pyrimidine dimers (CPDs) by DNA polymerase η, and error-pr...
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ژورنال
عنوان ژورنال: Eisei kagaku
سال: 1988
ISSN: 0013-273X
DOI: 10.1248/jhs1956.34.21